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Biocatalysis

A radical development for enzymatic fluorination

Nature Synthesis volume 3, pages 932–934 (2024)Cite this article

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Enzymes catalyse radical-mediated fluorine atom transfer reactions for enantioselective C(sp3)-F bond formation.

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Fig. 1: Biocatalytic enantioselective C(sp3)–F bond formation enabled by radical-mediated fluorine atom transfer by nonheme iron enzymes.

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  1. Twitter / X: @EJGChem

  2. Twitter / X: @KFBChem

Authors and Affiliations

  1. Department of Chemistry, Emory University, Atlanta, GA, USA

    Elizabeth J. Gross & Kyle F. Biegasiewicz

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  1. Elizabeth J. Gross
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  2. Kyle F. Biegasiewicz
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Correspondence to Kyle F. Biegasiewicz.

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The authors declare no competing interests.

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Gross, E.J., Biegasiewicz, K.F. A radical development for enzymatic fluorination. Nat. Synth 3, 932–934 (2024). https://doi.org/10.1038/s44160-024-00540-6

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