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Artificial metalloenzyme for the enantiodivergent synthesis of isoindolones

An artificial metalloenzyme based on streptavidin with a biotinylated Rh(III) cofactor provides enantioselective access to various isoindolones with different functional groups. Rational engineering of the streptavidin scaffold reverses the stereoselectivity, offering an enantiodivergent method for the synthesis of isoindolones.

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Fig. 1: Enantiodivergent synthesis of isoindolones.

References

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This is a summary of: Mukherjee, P. et al. Enantiodivergent synthesis of isoindolones catalysed by an Rh(III)-based artificial metalloenzyme. Nat. Synth. https://doi.org/10.1038/s44160-024-00533-5 (2024).

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Artificial metalloenzyme for the enantiodivergent synthesis of isoindolones. Nat. Synth 3, 803–804 (2024). https://doi.org/10.1038/s44160-024-00534-4

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