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Electrochemical synthesis

Radical approach for enantioselective amination

Enantioselective electrocatalysis is emerging as an increasingly versatile tool in organic synthesis. Now, by applying asymmetric Lewis acid catalysis with an elaborated ligand design, radical electrochemical amination is accomplished with full selectivity control.

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Fig. 1: Lewis acid-catalysed electrochemical radical amination as an innovative strategy for the synthesis of enantiomerically enriched α-amino carbonyl compounds.


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Correspondence to Lutz Ackermann.

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von Münchow, T., Ackermann, L. Radical approach for enantioselective amination. Nat. Synth (2023).

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