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A strategy for the site-selective allylic fluoroalkylation of terpenes

A strategy for the cobalt-catalysed allylic fluoroalkylation of terpenes can provide site-selective access to various fluorine-containing motifs under mild conditions. The extension of the protocol to a 2-mol-scale synthesis indicates the scalability of this method.

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Fig. 1: Inspiration and design for site-selective allylic fluoroalkylation.


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This is a summary of: Wang, S. et al. Cobalt-catalysed allylic fluoroalkylation of terpenes. Nat. Synth. (2023).

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A strategy for the site-selective allylic fluoroalkylation of terpenes. Nat. Synth (2023).

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