Assembly and functionalization of biologically active steroids continue to pose a synthetic challenge. Now, mining and engineering of selective P450 C–H hydroxylases provide a biocatalytic C14–H hydroxylation, which can be integrated into chemoenzymatic syntheses of C14-functionalized steroids.
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References
Peng, H. et al. Angew. Chem. Int. Ed. 60, 5414–5420 (2021).
Donova, M. V. & Egorova, O. V. Appl. Microbiol. Biotechnol. 94, 1423–1447 (2012).
Breslow, R., Corcoran, R., Dale, J. A., Liu, S. & Kalicky, P. J. Am. Chem. Soc. 96, 1973–1974 (1974).
Welzel, P. & Stein, H. Tetrahedron Lett. 22, 3385–3388 (1981).
Kirsch, G., Golde, R. & Neef, G. Tetrahedron Lett. 30, 4497–4500 (1989).
Renata, H., Zhou, Q. & Baran, P. S. Science 339, 59–63 (2013).
Li, J., Amatuni, A. & Renata, H. Curr. Opin. Chem. Biol. 55, 111–118 (2020).
Fasan, R. ACS Catal. 2, 647–666 (2012).
Song, F. et al. Nat. Synth. https://doi.org/10.1038/s44160-023-00280-z (2023).
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Zhao, L., Bo, Z. & Yang, Y. Enzymes on steroids. Nat. Synth 2, 699–700 (2023). https://doi.org/10.1038/s44160-023-00287-6
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DOI: https://doi.org/10.1038/s44160-023-00287-6