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Templated synthesis

Catalytic cavities control oligomer length

Catalytic templates produce oligomers of a defined length, moving beyond stoichiometric ratios of template to substrate. Bifunctional catalytic macrocycles with a defined cavity have a high affinity for the monomer but not the oligomer, enabling high-turnover oligomer synthesis.

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Fig. 1: Catalytic template for the synthesis of oligomers with a specific length.


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Correspondence to Rachel K. O’Reilly.

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Ferguson, C.T.J., O’Reilly, R.K. Catalytic cavities control oligomer length. Nat. Synth 2, 311–312 (2023).

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