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Paternò–Büchi pathways

The Paternò–Büchi reaction is a useful approach in organic synthesis to prepare oxetanes. Understanding the mechanism of this reaction is required for the prediction and control of the diastereoselectivity of the products.

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Fig. 1: Mechanisms of the Paternò–Büchi reaction.


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Correspondence to Norbert Hoffmann.

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Hoffmann, N. Paternò–Büchi pathways. Nat. Synth 2, 9–10 (2023).

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