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Alkene difunctionalization

Radical catalysis breaks and makes bonds

Controllable cleavage and conversion of strong C(sp3)–H bonds remains a challenging task in organic synthesis. Here, a reaction design combining hydrogen atom transfer and copper catalysis is developed which allows enantioselective alkene difunctionalization using aliphatic C–H bond activation.

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Fig. 1: Enantioselective alkene difunctionalization with compounds containing strong C(sp3)–H bonds.


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Correspondence to Lei Gong.

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Gong, L. Radical catalysis breaks and makes bonds. Nat. Synth 1, 915–916 (2022).

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