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Alkene difunctionalization

Radical catalysis breaks and makes bonds

Nature Synthesis volume 1, pages 915–916 (2022)Cite this article

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Controllable cleavage and conversion of strong C(sp3)–H bonds remains a challenging task in organic synthesis. Here, a reaction design combining hydrogen atom transfer and copper catalysis is developed which allows enantioselective alkene difunctionalization using aliphatic C–H bond activation.

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Fig. 1: Enantioselective alkene difunctionalization with compounds containing strong C(sp3)–H bonds.

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Authors and Affiliations

  1. Key Laboratory of Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, China

    Lei Gong

  2. Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen, China

    Lei Gong

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  1. Lei Gong
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Correspondence to Lei Gong.

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The author declares no competing interests.

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Gong, L. Radical catalysis breaks and makes bonds. Nat. Synth 1, 915–916 (2022). https://doi.org/10.1038/s44160-022-00174-6

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