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Cobalt selectively annulates

Nature Synthesis volume 1, pages 674–675 (2022)Cite this article

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Making chiral molecules by C–H bond activation using inexpensive, earth-abundant metal catalysts is challenging. Now, a cobalt salt combined with a salicyl-oxazoline ligand enables a C–H activation and annulation process and the introduction of axial chirality around a C–N bond.

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Fig. 1: Design of a simple and robust base metal catalyst for atroposelective C–H activation and annulation.

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  1. Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan

    Jun Kikuchi & Naohiko Yoshikai

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  1. Jun Kikuchi
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  2. Naohiko Yoshikai
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Correspondence to Naohiko Yoshikai.

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Kikuchi, J., Yoshikai, N. Cobalt selectively annulates. Nat. Synth 1, 674–675 (2022). https://doi.org/10.1038/s44160-022-00126-0

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