Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


Chiral amine synthesis refashioned

Catalytic intramolecular C–H amination via nitrene transfer typically yields N-heterocycles which can be unmasked to amino alcohols and diamines. Now, an enantioselective Co-catalysed 1,5-C–H amination to form cyclic sulfamidates from alcohols allows for ring opening to deliver diverse β-functionalized chiral amines.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Synthesis of β-functionalized chiral amines through Co-catalyzed 1,5-C(sp3)–H amination.


  1. Reddy, R. P. & Davies, H. M. L. Org. Lett. 8, 5013–5016 (2006).

    Article  CAS  Google Scholar 

  2. Zhou, Z. et al. Chem 6, 2024–2034 (2020).

    Article  CAS  Google Scholar 

  3. Lang, K., Hu, Y., Lee, W.-C. C. & Zhang, X. P. Nat. Synth. (2022).

    Article  Google Scholar 

  4. Lang, K., Torker, S., Wojtas, L. & Zhang, X. P. J. Am. Chem. Soc. 141, 12388–12396 (2019).

    Article  CAS  Google Scholar 

  5. Adams, C. S., Boralsky, L. A., Guzei, I. A. & Schomaker, J. M. J. Am. Chem. Soc. 134, 10807–10810 (2012).

    Article  CAS  Google Scholar 

  6. Bower, J. F., Rujirawanich, J. & Gallagher, T. Org. Biomol. Chem. 8, 1505–1519 (2010).

    Article  CAS  Google Scholar 

  7. Cardona, F. & Goti, A. Nat. Chem. 1, 269–275 (2009).

    Article  CAS  Google Scholar 

  8. Pendem, N. et al. J. Am. Chem. Soc. 135, 4884–4892 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Jennifer M. Schomaker.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zerull, E.E., Schomaker, J.M. Chiral amine synthesis refashioned. Nat. Synth 1, 506–507 (2022).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing