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Antibiotics the easy way

Aminoglycosides are an important class of potent antibiotics; however traditional synthetic approaches are lengthy and often rely on enzyme-based routes. Now, a formal enantioselective copper-catalysed hydroamination of benzene enables the total synthesis of the antibiotic (+)-ribostamycin in ten linear steps.

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Fig. 1: Copper-catalysed enantioselective hydroamination of benzene for the synthesis of the antibiotic (+)-ribostamycin.


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Correspondence to Andy A. Thomas.

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Arriaga, D.K., Thomas, A.A. Antibiotics the easy way. Nat. Synth 1, 504–505 (2022).

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