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Kolbe reaction goes reductive

The Kolbe electrolysis is a transformation renowned for forging C(sp3)–C(sp3) bonds. However, it is challenging to selectively make cross-products — that is, form new bonds from different partners — using this reaction. Now, a nickel-catalysed ‘reductive Kolbe’ reaction enables a decarboxylative cross-coupling approach.

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Fig. 1: Nickel-catalysed cross-coupling of carboxylic acids with in situ generation of redox active esters.


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Correspondence to Michael Findlater.

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Zhang, S., Findlater, M. Kolbe reaction goes reductive. Nat. Synth 1, 417–419 (2022).

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