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SYNTHETIC METHODOLOGY

Illuminating aryl cross-coupling with copper

Aryl ethers are privileged scaffolds in contemporary drug-discovery programs. Now, employment of triplet states of aryl halides enables copper-mediated cross-coupling with various alcohols for the expedient synthesis of aryl ethers.

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Fig. 1: Copper-mediated synthesis of aryl ethers via triplet states of aryl halides.

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Correspondence to Shunsuke Chiba.

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Li, H., Chiba, S. Illuminating aryl cross-coupling with copper. Nat. Synth 1, 339–340 (2022). https://doi.org/10.1038/s44160-022-00070-z

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