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3 + 3 makes the ring

Ring-forming reactions are at the heart of organic synthesis. Now, phenylene rings are synthesized from two isopropyl moieties on a gold surface. Resolving the intermediates of this (3+3) cycloaromatization reaction with atomic force microscopy offers mechanistic insight into the dimerization process.

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Fig. 1: Selected synthetic methods for obtaining a six-membered ring.


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Correspondence to Diego Peña or Leo Gross.

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Peña, D., Gross, L. 3 + 3 makes the ring. Nat. Synth 1, 260–261 (2022).

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