A method leverages protein structural data to predict T-cell receptor–peptide interactions for unseen peptide epitopes, which can be particularly useful for applications in cancer immunotherapy, autoimmunity studies, and vaccine design.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$99.00 per year
only $8.25 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Singh, N. K. et al. J. Immunol. 199, 2203–2213 (2017).
Hudson, D., Fernandes, R. A., Basham, M., Ogg, G. & Koohy, H. Nat. Rev. Immunol. 23, 511–521 (2023).
Vita, R. et al. Nucleic Acids Res. 47, D339–D343 (2019).
Karnaukhov, V. K. et al. Nat. Comput. Sci. https://doi.org/10.1038/s43588-024-00653-0 (2024).
Berman, H. M. et al. Nucleic Acids Res. 28, 235–242 (2000).
Abramson, J. et al. Nature https://doi.org/10.1038/s41586-024-07487-w (2024).
Yin, R. et al. Nucleic Acids Res. 51, W569–W576 (2023).
Yu, B. et al. Cell 185, 4904–4920.e22 (2022).
Zdinak, P. M. et al. Nat. Methods 21, 846–856 (2024).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Huo, M., Jiang, Y. & Li, S.C. Unlocking T-cell receptor–epitope insights with structural analysis. Nat Comput Sci 4, 475–476 (2024). https://doi.org/10.1038/s43588-024-00654-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s43588-024-00654-z
