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Genome informatics

Uncovering the genetic circuits that drive diseases

A hierarchical Bayesian method identifies cell-type specific changes in gene regulatory circuits in disease by integrating single-cell and three-dimensional measurements of the genome.

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Fig. 1: MAGICAL identifies cell-type specific gene regulatory circuits disrupted in disease.


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Correspondence to Pawel F. Przytycki.

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Przytycki, P.F. Uncovering the genetic circuits that drive diseases. Nat Comput Sci 3, 584–585 (2023).

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