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Gender inequality infiltrates the in silico modeling world

Gender inequality has been the unspoken truth, rampant for centuries. Although a deep-rooted cultural mindset, the inequality has reverse-translated from society into the way we study and practice science, and more currently, into the computational modeling world.

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  1. UNESCO Science Report: Towards 2030 (UNESCO, 2015);

  2. She Figs 2015 (Publications Office of the EU, 2016);

  3. Verdonk, P., Benschop, Y. W. M., De Haes, H. C. J. M. & Lagro-Janssen, T. L. M. Adv. Health Sci. Educ. Theory Pract. 14, 135–152 (2009).

    Article  Google Scholar 

  4. Bridging the Digital Gender Divide: Include, Upskill, Innovate (OECD, 2018);

  5. Shannon, G. et al. Lancet 393, 560–569 (2019).

    Article  Google Scholar 

  6. Gender Equity in Higher Education (SAGE, 2021);

  7. Solving the Equation: The Variables for Women’s Success in Engineering and Computing (AAUW, 2015);

  8. Stoet, G. & Geary, D. C. Psychol. Sci. 29, 581–593 (2018).

    Article  Google Scholar 

  9. Fields, R. D. Nature 510, 340 (2014).

    Article  Google Scholar 

  10. Becker, J. B., Prendergast, B. J. & Liang, J. W. Biol. Sex Differ. (2016).

  11. Drug Safety: Most Drugs Withdrawn in Recent Years Had Greater Health Risks for Women GAO-01-286R (US Government Printing Office, 2001).

  12. Nature 588, 196 (2020).

  13. Loomes, R., Hull, L. & Mandy, W. P. L. J. Am. Acad. Child Adolesc. Psychiatry 56, 466–474 (2017).

    Article  Google Scholar 

  14. Sindhu, K. N. et al. BMC Med. Res. Methodol. (2019).

  15. Gu, Q., Burt, V. L., Paulose-Ram, R. & Dillon, C. F. Am. J. Hypertens. 21, 789–798 (2008).

    Article  Google Scholar 

  16. Wang, L. et al. Hypertension 70, 1219–1227 (2017).

    Article  Google Scholar 

  17. Leete, J. & Layton, A. T. Comput. Biol. Med. 104, 139 (2019).

    Article  Google Scholar 

  18. Ahmed, S. & Layton, A. T. Am. J. Physiol. Ren. Physiol. 318, F888 (2020).

    Article  Google Scholar 

  19. Brunk, E. et al. Nat. Biotechnol. 36, 272–281 (2018).

    Article  Google Scholar 

  20. Thiele, I. et al. Mol. Syst. Biol. 16, e8982 (2020).

    Article  Google Scholar 

Download references


A.S.C. is supported by Accelerator program for Discovery in Brain disorders using Stem cells (ADBS) (jointly funded by the Department of Biotechnology, Government of India, and the Pratiksha trust; grant BT/PR17316/MED/31/326/2015). S.S. was supported by DST-INSPIRE Faculty award, Department of Science and Technology, India (DST/INSPIRE/04/2015/000036).

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A.S.C and S.S. contributed to the computational part, and M.S. was responsible for the social aspects of the study. All authors wrote the manuscript. S.S. designed and conceptualized the study.

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Correspondence to Swagatika Sahoo.

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The authors declare no competing interests.

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Chellappa, A.S., Sahoo, M. & Sahoo, S. Gender inequality infiltrates the in silico modeling world. Nat Comput Sci 2, 346–347 (2022).

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