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Towards scalable genomic data access

A new format for read depth annotations in genomic data makes access to metadata more scalable and efficient.

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Fig. 1: Genomic data representation and compression.


  1. 1.

    Stephens, Z. D. et al. PLoS Biol. 13, e1002195 (2015).

    Article  Google Scholar 

  2. 2.

    Hernaez, M., Pavlichin, D., Weissman, T. & Ochoa, I. Annu. Rev. Biomed. Data Sci. 2, 19–37 (2019).

    Article  Google Scholar 

  3. 3.

    Hou, H., Pedersen, B. & Quinlan, A. Nat. Comput. Sci. (2021).

    Article  Google Scholar 

  4. 4.

    Cock, P. J., Fields, C. J., Goto, N., Heuer, M. L. & Rice, P. M. Nucl. Acids Res. 38, 1767–1771 (2010).

    Article  Google Scholar 

  5. 5.

    Danecek, P. et al. GigaScience 10, giab008 (2021).

    Article  Google Scholar 

  6. 6.

    Numanagić, I. et al. Nat. Methods 13, 1005–1008 (2016).

    Article  Google Scholar 

  7. 7.

    Meng, Q., Ochoa, I. & Hernaez, M. Bioinformatics 36, 4810–4812 (2020).

    Article  Google Scholar 

  8. 8.

    Cover, T. M. & Thomas, J. A. Elements of Information Theory (John Wiley & Sons, 1999).

  9. 9.

    Kosseim, P. et al. Genome Biol. 15, 430 (2014).

    Article  Google Scholar 

  10. 10.

    Voges, J., Hernaez, M., Mattavelli, M. & Ostermann, J. Proc. IEEE (in the press).

Download references

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Correspondence to Mikel Hernaez.

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Hernaez, M. Towards scalable genomic data access. Nat Comput Sci 1, 391–392 (2021).

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