Multi-omics approaches have become a reality in both large genomics projects and small laboratories. However, the multi-omics research community still faces a number of issues that have either not been sufficiently discussed or for which current solutions are still limited. In this Perspective, we elaborate on these limitations and suggest points of attention for future research. We finally discuss new opportunities and challenges brought to the field by the rapid development of single-cell high-throughput molecular technologies.
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The code and data used to generate Fig. 3 are available on GitHub at https://github.com/ConesaLab/Perspective_Multi-Omics_Integration.
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This work has been funded by the Spanish Ministry of Science and Innovation with grant number BES-2016-076994 to A.A.-L.
The authors declare no competing interests.
Peer review information Nature Computational Science thanks Casey Greene and Terry Speed for their contribution to the peer review of this work. Handling editor: Fernando Chirigati, in collaboration with the Nature Computational Science team.
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Tarazona, S., Arzalluz-Luque, A. & Conesa, A. Undisclosed, unmet and neglected challenges in multi-omics studies. Nat Comput Sci 1, 395–402 (2021). https://doi.org/10.1038/s43588-021-00086-z