Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

GENOME INFORMATICS

Extracting insights from heterogeneous tissues

A limitation of data obtained from RNA-seq experiments is the presence of different types of cell expression, making it difficult to identify the contribution of cell-type composition or cell-type-specific expression. A new study addresses this problem by proposing a method for cell-type-aware analysis of RNA-seq data.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Interpreting gene expression differences in mixed samples.

References

  1. Aran, D., Sirota, M. & Butte, A. J. A. J. Nat. Commun. 6, 8971 (2015).

    Article  Google Scholar 

  2. Jin, C., Chen, M., Lin, D. & Sun, W. Nat. Comput. Sci. https://doi.org/10.1038/s43588-021-00055-6 (2021).

  3. Newman, A. M. et al. Nat. Methods 12, 453–457 (2015).

    Article  Google Scholar 

  4. Aran, D., Hu, Z. & Butte, A. J. xCell: digitally portraying the tissue cellular heterogeneity landscape. Genome Biol 18, 220 (2017).

    Article  Google Scholar 

  5. Love, M. I., Huber, W. & Anders, S. Genome Biol 15, 550 (2014).

    Article  Google Scholar 

  6. La Manno, G. et al. Nature 560, 494–498 (2018).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Dvir Aran.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Aran, D. Extracting insights from heterogeneous tissues. Nat Comput Sci 1, 247–248 (2021). https://doi.org/10.1038/s43588-021-00061-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43588-021-00061-8

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing