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Oxidative stress response protein delays ovarian aging by promoting stress granule clearance

Nature Aging volume 5, pages 1667–1668 (2025)Cite this article

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Analysis of granulosa cells from participants with age-related or pathological ovarian aging identified a crucial factor — NCOA7 — that promotes stress granule clearance via autophagy (‘granulophagy’), conferring protection against ovarian aging. Boosting NCOA7 activity or granulophagy alleviates senescence in granulosa cells and delays ovarian aging, suggesting new therapeutic strategies.

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Fig. 1: NCOA7 deficiency in granulosa cell senescence and ovarian aging.

References

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This is a summary of: Dong, T. et al. Stress granule clearance mediated by V-ATPase-interacting protein NCOA7 mitigates ovarian aging. Nat. Aging https://doi.org/10.1038/s43587-025-00927-w (2025).

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Oxidative stress response protein delays ovarian aging by promoting stress granule clearance. Nat Aging 5, 1667–1668 (2025). https://doi.org/10.1038/s43587-025-00960-9

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