We developed a single blood-based methylation test that estimates biological aging across 11 physiological systems. This multisystem measure predicts mortality and health outcomes more precisely than existing epigenetic clocks, and reveals distinct aging patterns that could guide personalized gerotherapeutic and geroprotective interventions.
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This is a summary of: Sehgal, R. et al. Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems. Nat. Aging https://doi.org/10.1038/s43587-025-00958-3 (2025).
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A blood DNA methylation test reveals how quickly each organ system is aging. Nat Aging 5, 1665–1666 (2025). https://doi.org/10.1038/s43587-025-00959-2
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DOI: https://doi.org/10.1038/s43587-025-00959-2
