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Healthy aging

Decoding the phenotypic mosaic of aging

Nature Aging (2024)Cite this article

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The Integrated Care for Older People program of the World Health Organization is intended as a catalyst to empower communities to cocreate personalized interventions and usher in an era of precision healthy longevity, in which the needs, values and preferences of older people are centered. A study from France now presents early screening data and reveals distinct phenotypic trajectories towards adverse outcomes.

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Fig. 1: Distinct phenotypes of intrinsic capacity impairments and risk of frailty, ADL disability and IADL disability.

References

  1. Asejeje, F. O. & Ogunro, O. B. Arch. Gerontol. Geriatr. Plus 1, 100003 (2024).

    Article  Google Scholar 

  2. Griffin, P. T. et al. Nat. Aging 4, 261–274 (2024).

    Article  CAS  PubMed  Google Scholar 

  3. Beard, J. R. et al. Lancet 387, 2145–2154 (2016).

    Article  PubMed  Google Scholar 

  4. de Souto Barreto, P. et al. Nat. Aging https://doi.org/10.1038/s43587-024-00684-2 (2024).

  5. Lin, C. S. et al. Front. Med. 8, 698728 (2022).

    Article  Google Scholar 

  6. Meng, L. C. et al. J. Nutr. Health Aging 26, 918–925 (2022).

    Article  PubMed  Google Scholar 

  7. Meng, L.-C. et al. Aging Dis. https://doi.org/10.14336/AD.2023.1115-1 (2023).

  8. Zhou, Y. et al. Arch. Gerontol. Geriatr. 124, 105452 (2024).

    Article  PubMed  Google Scholar 

  9. Salinas-Rodríguez, A., Fernández-Niño, J. A., Rivera-Almaraz, A. & Manrique-Espinoza, B. Int. J. Equity Health 23, 48 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Jayaraj, V. et al. Arch. Gerontol. Geriatr. Plus. 1, 100032 (2024).

    Article  Google Scholar 

Download references

Acknowledgements

This work is funded by the Interdisciplinary Research Center for Healthy Longevity of National Yang Ming Chiao Tung University from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education in Taiwan.

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Authors and Affiliations

  1. Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan

    Liang-Kung Chen

  2. Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan

    Liang-Kung Chen

  3. Taipei Municipal Gan-Dau Hospital (managed by Taipei Veterans General Hospital), Taipei, Taiwan

    Liang-Kung Chen

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  1. Liang-Kung Chen
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Correspondence to Liang-Kung Chen.

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Chen, LK. Decoding the phenotypic mosaic of aging. Nat Aging (2024). https://doi.org/10.1038/s43587-024-00686-0

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