A study from Ortega-Molina and colleagues uses mouse models with mildly elevated mTOR activity to investigate the stepwise process by which increased nutrient signaling affects healthy aging. These findings show how initial parenchymal damage caused by mTOR activity is followed by secondary myeloid inflammation, a multistage process that culminates in organ deterioration and reduced lifespan.
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Acknowledgements
Core support from MRC (MC_U120085810) and CRUK (C15075/A28647) funds research in the laboratory of J.G. Work in the group of H.M.C. is supported by MRC (MC-A654-5QB90).
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J.G. has acted as a consultant for Unity Biotechnology, Geras Bio, Myricx Pharma and Merck KGaA. Pfizer and Unity Biotechnology have funded research in J.G.’s laboratory. J.G. owns equity in Geras Bio. J.G. is a named inventor in MRC and Imperial College patents, both related to senolytic therapies. H.M.C. declares no competing interests.
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Cochemé, H.M., Gil, J. mTOR links nutrients, inflammaging and lifespan. Nat Aging 4, 1034–1035 (2024). https://doi.org/10.1038/s43587-024-00681-5
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DOI: https://doi.org/10.1038/s43587-024-00681-5
