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Compromised biogenesis of DHEA-S is implicated in primate adrenal aging


After discovering the sensitivity of the adrenal zona reticularis region to aging, we found that low-density lipoprotein receptor (LDLR) deficiency hampers both cholesterol uptake and dehydroepiandrosterone sulfate (DHEA-S) production. This finding reveals the cellular basis for age-related adrenal insufficiency and provides insights for the development of interventions to delay endocrine and systemic aging.

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Fig. 1: Cellular and molecular changes in primate adrenal aging.


  1. Warde, K. M., Smith, L. J. & Basham, K. J. Age-related changes in the adrenal cortex: insights and implications. J. Endocr.Soc. 7, bvad097 (2023). This review describes current understandings of adrenal aging.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Quinn, T. A. et al. Adrenal steroidogenesis following prenatal dexamethasone exposure in the spiny mouse. J. Endocrinol. 221, 347–362 (2014). This study describes the limitations of rodent models for studying adrenal DHEA-S secretion.

    Article  CAS  PubMed  Google Scholar 

  3. Muehlenbein, M. P. et al. Dehydroepiandrosterone-sulfate as a biomarker of senescence in male non-human primates. Exp. Gerontol. 38, 1077–1085 (2003). This work describes a substantial decrease in DHEA-S levels during nonhuman primate aging.

    Article  CAS  PubMed  Google Scholar 

  4. Sun, S. et al. CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord. Nature 624, 611–620 (2023). This article offers an analysis of the single-nucleus transcriptome combined with the transcriptome system in nonhuman primate aging.

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Jing, Y. et al. Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation. Cell Stem Cell 30, 1452.e10–1471.e10 (2023). This article presents an example of the use of a CRISPR–Cas9 cell-based gene-editing system in age-related studies.

    Article  Google Scholar 

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This is a summary of: Wang, Q. et al. Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland. Nat. Aging, (2024).

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Compromised biogenesis of DHEA-S is implicated in primate adrenal aging. Nat Aging 4, 291–292 (2024).

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