Leveraging a single regression model based on conserved cytosines, we can now measure age in all mammalian tissues. This pan-mammalian epigenetic clock model confirms that aging is conserved across mammalian species at select regions of the DNA, which will accelerate the applicability of research findings from model organisms to humans.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Horvath, S. DNA methylation age of human tissues and cell types. Genome Biol. 14, 3156 (2013). This article presents a pan-tissue epigenetic clock for human cells.
Horvath, S. & Raj, K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat. Rev. Genet. 19, 371–384 (2018). A review that discusses epigenetic clocks and a related aging theory.
Arneson, A., Haghani, A., Ernst, J. & Horvath, S. A mammalian methylation array for profiling methylation levels at conserved sequences. Nat. Commun. 13, 783 (2022). This article describes the mammalian methylation array platform.
Gems, D. The hyperfunction theory: an emerging paradigm for the biology of aging. Ageing Res. Rev. 74, 101557 (2022). This article reviews pseudo-programmatic and hyperfunction theories of aging.
de Magalhães, J. P. Ageing as a software design flaw. Genome Biol. 24, 51 (2023). This article explores the hypothesis that aging is caused by a software design flaw.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Lu, A. T. et al. Universal DNA methylation age across mammalian tissues. Nat. Aging https://doi.org/10.1038/s43587-023-00462-6 (2023)
Rights and permissions
About this article
Cite this article
Pan-mammalian methylation clocks reveal evolutionarily conserved aging effects. Nat Aging 3, 1055–1056 (2023). https://doi.org/10.1038/s43587-023-00463-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s43587-023-00463-5
