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Pan-mammalian methylation clocks reveal evolutionarily conserved aging effects

Leveraging a single regression model based on conserved cytosines, we can now measure age in all mammalian tissues. This pan-mammalian epigenetic clock model confirms that aging is conserved across mammalian species at select regions of the DNA, which will accelerate the applicability of research findings from model organisms to humans.

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Fig. 1: Universal pan-mammalian epigenetic clocks and maximum lifespan.


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This is a summary of: Lu, A. T. et al. Universal DNA methylation age across mammalian tissues. Nat. Aging (2023)

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Pan-mammalian methylation clocks reveal evolutionarily conserved aging effects. Nat Aging 3, 1055–1056 (2023).

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