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Prolonged heterochronic parabiosis decreases biological age and promotes longevity in old mice

By applying deep molecular profiling to our long-term mouse parabiosis model, we reveal reduced epigenetic age in old mice that shared circulation with young mice. The rejuvenation effect is sustained at two months after detachment, leading to lifespan extension and improved physical function, and is associated with rejuvenated transcriptomic signatures.

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Fig. 1: Prolonged heterochronic parabiosis extends lifespan and decreases epigenetic aging in old mice.


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This is a summary of: Zhang, B. et al. Multi-omic rejuvenation and lifespan extension upon exposure to youthful circulation. Nat. Aging (2023).

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Prolonged heterochronic parabiosis decreases biological age and promotes longevity in old mice. Nat Aging 3, 917–918 (2023).

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