By applying deep molecular profiling to our long-term mouse parabiosis model, we reveal reduced epigenetic age in old mice that shared circulation with young mice. The rejuvenation effect is sustained at two months after detachment, leading to lifespan extension and improved physical function, and is associated with rejuvenated transcriptomic signatures.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
McCay, C. M., Pope, F. & Lunsford, W. Experimental prolongation of the life span. Bull. NY Acad. Med. 32, 91–101 (1956). One of the first publications using the parabiosis model to study aging.
Conboy, I. M. et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433, 760–764 (2005). A study that shows the rejuvenating effects of heterochronic parabiosis across multiple aged tissues.
Villeda, S. A. et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat. Med. 20, 659–663 (2014). A study that shows that systemic delivery of young plasma can recapitulate the beneficial effects of parabiosis on cognition.
Baht, G. S. et al. Exposure to a youthful circulation rejuvenates bone repair through modulation of beta-catenin. Nat. Commun. 6, 7131 (2015). This study demonstrated enhanced bone repair with heterochronic parabiosis.
Poganik, R. J. et al. Biological age is increased by stress and restored upon recovery. Cell Metab. 35, 807–820 (2023). This paper establishes that biological age reversibly increases in young animals upon heterochronic parabiosis.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Zhang, B. et al. Multi-omic rejuvenation and lifespan extension upon exposure to youthful circulation. Nat. Aging https://doi.org/10.1038/s43587-023-00451-9 (2023).
About this article
Cite this article
Prolonged heterochronic parabiosis decreases biological age and promotes longevity in old mice. Nat Aging 3, 917–918 (2023). https://doi.org/10.1038/s43587-023-00452-8