Liu and colleagues investigate the effects that ovarian aging may have in granulosa cell-to-oocyte communication and demonstrate that oocyte rejuvenation and the extension of reproductive lifespan is possible by increasing lipid metabolism in granulosa cells in mouse.
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The authors declare no competing interests.
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Blengini, C.S., Schindler, K. Follicular communication breakdown in aging ovaries. Nat Aging 3, 636–637 (2023). https://doi.org/10.1038/s43587-023-00435-9