The mysteries behind immune aging and its related inflammation are being unmasked. Jin et al. reveal that the defective turnover of damaged mitochondria in CD4+ T cells from older individuals results in the exacerbated secretion of mitochondrial DNA, which fuels inflammaging and impairs immune responses.
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References
Jin, J. et al. Nat. Aging https://doi.org/10.1038/s43587-023-00399-w (2023).
Carrasco, E. et al. Nat. Rev. Immunol. 22, 97–111 (2022).
Mogilenko, D. A. et al. Immunity 54, 99–115 (2021).
Baixauli, F. et al. Cell Metab. 22, 485–498 (2015).
Desdín-Micó, G. et al. Science 368, 1371–1376 (2020).
Wu, T. et al. Sci. Immunol. 1, eaai8593 (2016).
Bektas, A. et al. Aging 11, 9234–9263 (2019).
Jin, J. et al. Sci. Adv. 6, eaba1808 (2020).
Pinti, M. et al. Eur. J. Immunol. 44, 1552–1562 (2014).
Marchi, S., Guilbaud, E., Tait, S. W. G., Yamazaki, T. & Galluzzi, L. Nat. Rev. Immunol. 23, 159–173 (2023).
Zecchini, V. et al. Nature 615, 499–506 (2023).
Torralba, D. et al. Nat. Commun. 9, 2658 (2018).
Palmer, D. C. et al. Med. 3, 682–704 (2022).
Zhang, H., Puleston, D. J. & Simon, A. K. Trends Mol. Med. 22, 671–686 (2016).
Acknowledgements
The authors were supported by the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI19/855), the European Regional Development Fund (ERDF) and the European Commission through H2020-EU.1.1, European Research Council grant ERC-2021-CoG-101044248-Let T Be, and the Y2020/BIO-6350 NutriSION-CM synergy grant from Comunidad de Madrid. M.M.G.d.l.H. is supported by a FPU grant (FPU19/02576) from Ministerio de Ciencia, Innovación y Universidades (Spain).
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Gómez de las Heras, M.M., Mittelbrunn, M. Old T cells pollute with mito-litter. Nat Aging 3, 475–476 (2023). https://doi.org/10.1038/s43587-023-00412-2
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DOI: https://doi.org/10.1038/s43587-023-00412-2