Epigenetic changes are a driver of senescence and occur during aging. A study in Nature Aging shows how chromatin-mediated loss of transcription fidelity, previously shown in yeast and worms, also occurs in mammalian cells and could constitute a new hallmark of senescence and aging.
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References
Gorgoulis, V. et al. Cell 179, 813–827 (2019).
Baker, D. J. et al. Nature 530, 184–189 (2016).
Criscione, S. W., Teo, Y. V. & Neretti, N. Trends Genet. 32, 751–761 (2016).
Martínez-Zamudio, R. I. et al. Nat. Cell Biol. 22, 842–855 (2020).
Tasdemir, N. et al. Cancer Discov. 6, 612–629 (2016).
De Cecco, M. et al. Nature 566, 73–78 (2019).
Liu, X. et al. Cell 186, 287–304 (2023).
Sen, P. et al. Nat. Aging https://doi.org/10.1038/s43587-023-00384-3 (2023).
Sen, P. et al. Genes Dev. 29, 1362–1376 (2015).
Mahmoudi, S., Xu, L. & Brunet, A. Nat. Cell Biol. 21, 32–43 (2019).
Acknowledgements
Core support from MRC (MC_U120085810) and CRUK (C15075/A28647) fund research in J.G.’s laboratory.
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J.G. has acted as a consultant for Unity Biotechnology, Geras Bio, Myricx Pharma and Merck KGaA. Pfizer and Unity Biotechnology have funded research in J.G.’s laboratory (unrelated to the work presented here). J.G. owns equity in Geras Bio. J.G. is a named inventor in MRC and Imperial College patents, both related to senolytic therapies (the patents are no related to the work presented here). N.I. declares no competing interests.
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Isima, N., Gil, J. Spurious transcription may be a hallmark of aging. Nat Aging 3, 374–375 (2023). https://doi.org/10.1038/s43587-023-00398-x
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DOI: https://doi.org/10.1038/s43587-023-00398-x