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Spurious transcription may be a hallmark of aging

Nature Aging volume 3, pages 374–375 (2023)Cite this article

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Epigenetic changes are a driver of senescence and occur during aging. A study in Nature Aging shows how chromatin-mediated loss of transcription fidelity, previously shown in yeast and worms, also occurs in mammalian cells and could constitute a new hallmark of senescence and aging.

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Fig. 1: Conversion of intragenic enhancers to promoters drives cryptic transcription in senescent cells.

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Acknowledgements

Core support from MRC (MC_U120085810) and CRUK (C15075/A28647) fund research in J.G.’s laboratory.

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Authors and Affiliations

  1. MRC London Institute of Medical Sciences (LMS), London, UK

    Nikita Isima & Jesús Gil

  2. Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK

    Nikita Isima & Jesús Gil

Authors
  1. Nikita Isima
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  2. Jesús Gil
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Correspondence to Jesús Gil.

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Competing interests

J.G. has acted as a consultant for Unity Biotechnology, Geras Bio, Myricx Pharma and Merck KGaA. Pfizer and Unity Biotechnology have funded research in J.G.’s laboratory (unrelated to the work presented here). J.G. owns equity in Geras Bio. J.G. is a named inventor in MRC and Imperial College patents, both related to senolytic therapies (the patents are no related to the work presented here). N.I. declares no competing interests.

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Isima, N., Gil, J. Spurious transcription may be a hallmark of aging. Nat Aging 3, 374–375 (2023). https://doi.org/10.1038/s43587-023-00398-x

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