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Stem cell aging

Seeing is believing: old clones die young

Nature Aging volume 3, pages 371–373 (2023)Cite this article

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The ability of adult neural stem cells to produce new neurons (neurogenesis) declines markedly during aging, but exactly how this occurs is largely unknown. Using sophisticated in vivo imaging, a study in Nature Aging shows that aging affects several steps of neurogenesis — most notably, increasing the death of newborn clones.

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Fig. 1: Aging affects neurogenesis dynamics.

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Acknowledgements

We apologize for not being able to cite much primary literature because of space limits. This work was supported by P01AG036695 (A.B.) and Stanford Medical Scientist Training Program grant T32-GM007365 (O.Y.Z.).

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Authors and Affiliations

  1. Department of Genetics, Stanford University, Stanford, CA, USA

    Olivia Y. Zhou & Anne Brunet

  2. Stanford Biophysics Program, Stanford University, Stanford, CA, USA

    Olivia Y. Zhou

  3. Stanford Medical Scientist Training Program, Stanford University, Stanford, CA, USA

    Olivia Y. Zhou

  4. Glenn Laboratories for the Biology of Aging, Stanford University, Stanford, CA, USA

    Anne Brunet

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  1. Olivia Y. Zhou
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  2. Anne Brunet
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Correspondence to Anne Brunet.

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Zhou, O.Y., Brunet, A. Seeing is believing: old clones die young. Nat Aging 3, 371–373 (2023). https://doi.org/10.1038/s43587-023-00394-1

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