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Improved prediction of type 2 diabetes onset from blood-based biomarkers

Nature Aging volume 3, pages 378–379 (2023)Cite this article

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Clinical predictors of type 2 diabetes can be improved by considering blood-based DNA methylation scores. We derive the scores in 9,835 Scottish individuals and then test their performance against clinical predictors in 4,778 additional Scottish volunteers and 1,451 German volunteers.

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Fig. 1: Receiver operating characteristic curves for a model with traditional risk factors versus models that also contained a DNA methylation ‘EpiScore’.

References

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This is a summary of: Cheng, Y. et al. Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes. Nat. Aging, https://doi.org/10.1038/s43587-023-00391-4 (2023).

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Improved prediction of type 2 diabetes onset from blood-based biomarkers. Nat Aging 3, 378–379 (2023). https://doi.org/10.1038/s43587-023-00390-5

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