We found evolutionarily conserved astrocyte and microglia subpopulations shared across multiple brain regions. We reveal similarities and differences between Alzheimer’s disease glia and Parkinson’s disease glia, as well as regional variance linked to disease pathology and neurodegeneration.
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References
Fu, H., Hardy, J. & Duff, K. E. Selective vulnerability in neurodegenerative diseases. Nat. Neurosci. 21, 1350–1358 (2018). A review article that describes the biology underlying selective neuronal vulnerability.
Pandya, V. A. & Patani, R. Region-specific vulnerability in neurodegeneration: lessons from normal ageing. Ageing Res. Rev. 67, 101311 (2021). A review article that describes normal aging in relation to regional vulnerability.
Gan, L., Cookson, M. R., Petrucelli, L. & La Spada, A. R. Converging pathways in neurodegeneration, from genetics to mechanisms. Nat. Neurosci. 21, 1300–1309 (2018). A review article on the common pathways shared by neurodegenerative diseases.
Hickman, S., Izzy, S., Sen, P., Morsett, L. & El Khoury, J. Microglia in neurodegeneration. Nat. Neurosci. 21, 1359–1369 (2018). A review article that summarizes the roles of microglia in neurodegeneration.
Brandebura, A. N., Paumier, A., Onur, T. S. & Allen, N. J. Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders. Nat. Rev. Neurosci. 24, 23–39 (2023). A review article that summarizes the roles of astrocytes in neurodegeneration.
Grubman, A. et al. A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation. Nat. Neurosci. 22, 2087–2097 (2019). The source of the entorhinal cortex data.
Lau, S. F., Cao, H., Fu, A. K. Y. & Ip, N. Y. Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease. Proc. Natl Acad. Sci. USA 117, 25800–25809 (2020). The source of the prefrontal cortex data.
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This is a summary of: Xu, J. et al. Human striatal glia differentially contribute to AD- and PD-specific neurodegeneration. Nat. Aging https://doi.org/10.1038/s43587-023-00363-8 (2023).
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Shared and disease-specific glial gene expression changes in neurodegenerative diseases. Nat Aging 3, 246–247 (2023). https://doi.org/10.1038/s43587-023-00378-1
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DOI: https://doi.org/10.1038/s43587-023-00378-1
