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Liver aging

Aging breaks liver vascular ‘zone defense’

Wang Lin and his colleagues explore how aging reprograms spatially unique pathways in liver endothelial cells to cause fibrosis. They find that loss of KIT in liver endothelial cells close to the central vein upregulates the chemokine receptor CXCR4 to stimulate inflammation, enhance fibrosis and increase lipid accumulation in aged liver.

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Fig. 1: Aging suppresses the spatially specific marker KIT in LSECs to induce CXCR4.

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Acknowledgements

We are grateful to Y. Ren and X. Huang for their helpful discussion and input. The authors are supported by National Natural Science Foundation of China (82125002, 81925005, 92268201, U21A20333).

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Correspondence to Zhongwei Cao or Bi-Sen Ding.

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Cao, Z., Ding, BS. Aging breaks liver vascular ‘zone defense’. Nat Aging 3, 242–243 (2023). https://doi.org/10.1038/s43587-023-00371-8

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