Cellular senesence is believed to be a driver of aging. We designed and synthesized a photosensitive prodrug that destroys senescent cells by integrating multiple technologies that combine biomarker guidance with a fluorescence tag, target-site anchoring and photodynamic therapy, providing a strategy for monitoring and specifically eliminating senescent cells to regulate aging.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Zhu, Y. et al. The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 14, 644–658 (2015). This paper reports the combination of dasatinib and quercetin as a senolytic drug.
Xu, M. et al. Senolytics improve physical function and increase lifespan in old age. Nat. Med. 24, 1246–1256 (2018). This paper reports that transplanting SnCs into young mice causes persistent physical dysfunction, which can be alleviated by senolytic drugs.
Johmura, Y. et al. Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders. Science 371, 265–270 (2021). This paper reports that senescent cells rely on glutaminolysis, and its inhibition offers a promising strategy for inducing senolysis in vivo.
Micco, R. D. et al. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat. Rev. Mol. Cell Biol. 22, 75–95 (2021). A review that presents the mechanisms and modulators of cellular senescence establishment and the recent works of senolytic and senomorphic therapies in aging and aging-associated diseases.
Dimri, G. P. et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA 92, 9363–9367 (1995). This paper reports that SA-β-gal is a useful marker of senescence.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Shi, D. et al. Photoactivatable senolysis with single-cell resolution delays aging. Nat. Aging https://doi.org/10.1038/s43587-023-00360-x (2023).
Rights and permissions
About this article
Cite this article
A senolytic strategy integrating multiple technologies delays aging. Nat Aging 3, 244–245 (2023). https://doi.org/10.1038/s43587-023-00369-2