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A senolytic strategy integrating multiple technologies delays aging

Cellular senesence is believed to be a driver of aging. We designed and synthesized a photosensitive prodrug that destroys senescent cells by integrating multiple technologies that combine biomarker guidance with a fluorescence tag, target-site anchoring and photodynamic therapy, providing a strategy for monitoring and specifically eliminating senescent cells to regulate aging.

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Fig. 1: Selective clearance of SnCs.


  1. Zhu, Y. et al. The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 14, 644–658 (2015). This paper reports the combination of dasatinib and quercetin as a senolytic drug.

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This is a summary of: Shi, D. et al. Photoactivatable senolysis with single-cell resolution delays aging. Nat. Aging (2023).

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A senolytic strategy integrating multiple technologies delays aging. Nat Aging 3, 244–245 (2023).

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