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Microglial cGAS–STING links innate immunity and Alzheimer’s disease

Neuroinflammation is increasingly recognized as an important pathological trigger for the development and progression of Alzheimer’s disease. However, the molecular mechanism remains largely unclear. We identify activation of the neuroimmune cGAS–STING signaling pathway as a critical molecular link, predominantly in microglia, that contributes to Alzheimer’s disease pathogenesis.

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Fig. 1: Activation of the cGAS–STING pathway contributes to Alzheimer’s disease pathogenesis.


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This is a summary of: Xie, X. et al. Activation of innate immune cGAS-STING pathway contributes to Alzheimer’s pathogenesis in 5×FAD mice. Nat. Aging, (2023).

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Microglial cGAS–STING links innate immunity and Alzheimer’s disease. Nat Aging 3, 155–156 (2023).

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