Mouse frailty can be measured with a frailty index by manually counting health deficits. Vivek Kumar and colleagues use machine learning to extract physical performance deficits from video data to create a ‘visual frailty index’. This automated technique may facilitate high-throughput research into new frailty interventions.
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References
Vaupel, J. W., Manton, K. G. & Stallard, E. Demography 16, 439–454 (1979).
Howlett, S. E., Rutenberg, A. D. & Rockwood, K. Nat. Aging 1, 651–665 (2021).
Mitnitski, A. B., Mogilner, A. J. & Rockwood, K. ScientificWorldJournal 1, 323–336 (2001).
Whitehead, J. C. et al. J. Gerontol. A Biol. Sci. Med. Sci. 69, 621–632 (2014).
Kane, A. E. et al. J. Gerontol. A Biol. Sci. Med. Sci. 70, 694–695 (2015).
Feridooni, H. A., Sun, M. H., Rockwood, K. & Howlett, S. E. J. Gerontol. A Biol. Sci. Med. Sci. 70, 686–693 (2015).
Kane, A. E., Ayaz, O., Ghimire, A., Feridooni, H. A. & Howlett, S. E. Can. J. Physiol. Pharmacol. 95, 1149–1155 (2017).
Hession, L. E., Sabnis, G. S., Churchill, G. A. & Kumar, V. Nat. Aging https://doi.org/10.1038/s43587-022-00266-0 (2022).
Mach, J. et al. Exp. Gerontol. 161, 111700 (2022).
Fielder, E. et al. eLife 11, e75492 (2022).
Keller, K., Kane, A., Heinze-Milne, S., Grandy, S. A. & Howlett, S. E. J. Gerontol. A Biol. Sci. Med. Sci. 74, 1149–1157 (2019).
Yu, D. et al. Cell Rep. 29, 236–248.e3 (2019).
Bisset, E. S., Heinze-Milne, S., Grandy, S. A. & Howlett, S. E. J. Gerontol. A Biol. Sci. Med. Sci. 77, 41–46 (2022).
Seibenhener, M. L. & Wooten, M. C. JoVE 96, e52434 (2015).
Kane, A. E. & Howlett, S. E. Mech. Ageing Dev. 198, 111546 (2021).
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Bisset, E.S., Howlett, S.E. Machine learning to spot frailty in aging mice. Nat Aging 2, 684–685 (2022). https://doi.org/10.1038/s43587-022-00267-z
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DOI: https://doi.org/10.1038/s43587-022-00267-z