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Landscape of somatic mutations in aging human heart muscle cells

Using single-cell whole-genome sequencing, we identified and characterized the landscape of somatic single-nucleotide variants (sSNVs) in single cardiomyocytes from individuals across the human lifespan. Aged cardiomyocytes were found to have a higher burden of sSNVs and show mutational signatures that suggest failed repair of oxidative DNA damage.

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Fig. 1: sSNVs in the aging heart.

References

  1. Dhingra, R. & Vasan, R. S. Age as a risk factor. Med. Clin. N. Am. 96, 87–91 (2012). A Review article that presents age as an independent risk factor.

    Article  Google Scholar 

  2. Miller, M. B., Reed, H. C. & Walsh, C. A. Brain somatic mutation in aging and Alzheimer’s disease. Annu. Rev. Genomics Hum. Genet. 22, 239–256 (2021). A Review article that presents the somatic mutational burden in aging and diseased brain cells.

    Article  Google Scholar 

  3. Dou, Y., Gold, H. D., Luquette, L. J. & Park, P. J. Detecting somatic mutations in normal cells. Trends Genet. 34, 545–557 (2018). A Review article that presents the challenges in detecting sSNV from normal and non-cancer tissue.

    CAS  Article  Google Scholar 

  4. Koh, G., Degasperi, A., Zou, X., Momen, S. & Nik-Zainal, S. Mutational signatures: emerging concepts, caveats and clinical applications. Nat. Rev. Cancer 21, 619–637 (2021). A Review article that suggests how mutational signatures could be used to decipher disease mechanisms.

    CAS  Article  Google Scholar 

  5. Chatterjee, N. & Walker, G. C. Mechanisms of DNA damage, repair, and mutagenesis. Environ. Mol. Mutagen. 58, 235–263 (2017). A Review article that presents various DNA damage and repair pathways.

    CAS  Article  Google Scholar 

Download references

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This is a summary of: Choudhury, S. et al. Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity. Nat. Aging https://doi.org/10.1038/s43587-022-00261-5 (2022).

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Landscape of somatic mutations in aging human heart muscle cells. Nat Aging 2, 686–687 (2022). https://doi.org/10.1038/s43587-022-00264-2

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