Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Landscape of somatic mutations in aging human heart muscle cells

Using single-cell whole-genome sequencing, we identified and characterized the landscape of somatic single-nucleotide variants (sSNVs) in single cardiomyocytes from individuals across the human lifespan. Aged cardiomyocytes were found to have a higher burden of sSNVs and show mutational signatures that suggest failed repair of oxidative DNA damage.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: sSNVs in the aging heart.


  1. Dhingra, R. & Vasan, R. S. Age as a risk factor. Med. Clin. N. Am. 96, 87–91 (2012). A Review article that presents age as an independent risk factor.

    Article  Google Scholar 

  2. Miller, M. B., Reed, H. C. & Walsh, C. A. Brain somatic mutation in aging and Alzheimer’s disease. Annu. Rev. Genomics Hum. Genet. 22, 239–256 (2021). A Review article that presents the somatic mutational burden in aging and diseased brain cells.

    Article  Google Scholar 

  3. Dou, Y., Gold, H. D., Luquette, L. J. & Park, P. J. Detecting somatic mutations in normal cells. Trends Genet. 34, 545–557 (2018). A Review article that presents the challenges in detecting sSNV from normal and non-cancer tissue.

    CAS  Article  Google Scholar 

  4. Koh, G., Degasperi, A., Zou, X., Momen, S. & Nik-Zainal, S. Mutational signatures: emerging concepts, caveats and clinical applications. Nat. Rev. Cancer 21, 619–637 (2021). A Review article that suggests how mutational signatures could be used to decipher disease mechanisms.

    CAS  Article  Google Scholar 

  5. Chatterjee, N. & Walker, G. C. Mechanisms of DNA damage, repair, and mutagenesis. Environ. Mol. Mutagen. 58, 235–263 (2017). A Review article that presents various DNA damage and repair pathways.

    CAS  Article  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Choudhury, S. et al. Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity. Nat. Aging (2022).

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Landscape of somatic mutations in aging human heart muscle cells. Nat Aging 2, 686–687 (2022).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing