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COMPUTATIONAL BIOLOGY

Single-cell gene regulation across aging tissues

Nature Aging volume 2, pages 468–470 (2022)Cite this article

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Transcription factors can control cell identity and function in health and disease. However, how they do so during aging is incompletely explored. Maity and colleagues identify age-related changes in gene regulation by analyzing the expression patterns of transcription-factor target genes in single-cell transcriptomics data.

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Fig. 1: Assessing age-related changes in mouse gene regulatory activity across cell types from the TMS single-cell dataset.

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Authors and Affiliations

  1. Integrative Genomics of Ageing Group, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK

    Cyril Lagger & João Pedro de Magalhães

Authors
  1. Cyril Lagger
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  2. João Pedro de Magalhães
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Corresponding authors

Correspondence to Cyril Lagger or João Pedro de Magalhães.

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Competing interests

J.P.d.M. is an advisor/consultant for the Longevity Vision Fund, NOVOS, YouthBio Therapeutics and the founder of Magellan Science Ltd, a company providing consulting services in longevity science. C.L. has no competing interest to declare.

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Lagger, C., de Magalhães, J.P. Single-cell gene regulation across aging tissues. Nat Aging 2, 468–470 (2022). https://doi.org/10.1038/s43587-022-00238-4

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