Frailty is an important age-related prognostic for mortality, and little is known about its immune landscape. Luo et al.1 use single-cell profiling to gather a comprehensive understanding of immune changes that happen from birth to old age, and provide new insights into the often-overlooked state of frailty.
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The authors declare no competing interests.
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De Maeyer, R.P.H., Akbar, A.N. Aging and frailty immune landscape. Nat Aging 2, 280–281 (2022). https://doi.org/10.1038/s43587-022-00208-w