Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

IMMUNITY

Aging and frailty immune landscape

Nature Aging volume 2, pages 280–281 (2022)Cite this article

Subjects

Frailty is an important age-related prognostic for mortality, and little is known about its immune landscape. Luo et al.1 use single-cell profiling to gather a comprehensive understanding of immune changes that happen from birth to old age, and provide new insights into the often-overlooked state of frailty.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Luo, O. J. et al. Nat. Aging, https://doi.org/10.1038/s43587-022-00198-9 (2022).

  2. Nikolich-Žugich, J. Nat. Immunol. 19, 10–19 (2018).

    Article  PubMed  Google Scholar 

  3. Fulop, T. et al. Biogerontology 17, 147–157 (2016).

    Article  CAS  PubMed  Google Scholar 

  4. Aiello, A. et al. Front. Immunol. 10, 2247 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Dent, E. et al. J. Am. Med. Dir. Assoc. 18, 564–575 (2017).

    Article  PubMed  Google Scholar 

  6. Morley, J. E. et al. J. Am. Med. Dir. Assoc. 14, 392–397 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Vaupel, J. W., Manton, K. G. & Stallard, E. Demography 16, 439–454 (1979).

    Article  CAS  PubMed  Google Scholar 

  8. Müller, L., Di Benedetto, S. & Pawelec, G. Subcell. Biochem. 91, 21–43 (2019).

    Article  PubMed  Google Scholar 

  9. Chen, G. et al. Cell Rep. 19, 569–583 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Wang, G. C. et al. Am. J. Epidemiol. 171, 1144–1152 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Matheï, C., Vaes, B., Wallemacq, P. & Degryse, J. J. Am. Geriatr. Soc. 59, 2201–2208 (2011).

    Article  PubMed  Google Scholar 

  12. Pereira, B. I. et al. Nat. Immunol. 21, 684–694 (2020).

    Article  CAS  PubMed  Google Scholar 

  13. Vallejo, A. N. et al. Ageing Res. Rev. 10, 354–361 (2011).

    Article  CAS  PubMed  Google Scholar 

  14. Yoshimoto, R., Mayeda, A., Yoshida, M. & Nakagawa, S. Biochim. Biophys. Acta 1859, 192–199 (2016).

    Article  CAS  PubMed  Google Scholar 

  15. Giovannini, S. et al. J. Am. Geriatr. Soc. 59, 1679–1685 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Medicine, University College London, London, UK

    Roel P. H. De Maeyer & Arne N. Akbar

Authors
  1. Roel P. H. De Maeyer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Arne N. Akbar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Arne N. Akbar.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

De Maeyer, R.P.H., Akbar, A.N. Aging and frailty immune landscape. Nat Aging 2, 280–281 (2022). https://doi.org/10.1038/s43587-022-00208-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43587-022-00208-w

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research