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The energy–splicing resilience axis hypothesis of aging

Nature Aging volume 2, pages 182–185 (2022)Cite this article

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Aging can be conceptualized as the stochastic accumulation of damage and loss of resilience leading to organism demise. Resilience mechanisms that repair, recycle or replace damaged molecules and organelles are energy-demanding, therefore energy availability is essential to healthy aging. We propose that changes in mitochondrial and energy status regulate RNA splicing and that splicing is a resilience strategy that preserves energetic homeostasis with aging.

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Fig. 1: Skeletal muscle proteomics.
Fig. 2: Energy–splicing resilience axis.

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Acknowledgements

This research was supported by the Intramural Research Program of the National Institute on Aging, NIH.

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Authors and Affiliations

  1. Biomedical Research Center, National Institute on Aging, National Institute of Health, Baltimore, MD, USA

    Luigi Ferrucci, Stefano Donegà & Myriam Gorospe

  2. Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium

    David M. Wilson III

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  1. Luigi Ferrucci
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  2. David M. Wilson III
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  3. Stefano Donegà
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  4. Myriam Gorospe
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Contributions

L.F. conceived the axis model, and all authors participated in identifying relevant literature, refining the model and writing and editing the Comment.

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Correspondence to Luigi Ferrucci.

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The authors declare no competing interests.

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Ferrucci, L., Wilson, D.M., Donegà, S. et al. The energy–splicing resilience axis hypothesis of aging. Nat Aging 2, 182–185 (2022). https://doi.org/10.1038/s43587-022-00189-w

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