In cultured cells and in mice with accelerated aging, brief bursts of Yamanaka reprogramming factors reverse some molecular and functional deficits of aging without inducing pluripotency or teratomas. Browder et al. show that partial reprogramming regimens rejuvenate some tissues of physiologically aged mice without overt safety concerns.
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A.M. declares no competing interests. G.Q.D. holds a grant from the Milky Way Research Foundation to study partial reprogramming and rejuvenation of tissue function.
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Markel, A., Daley, G.Q. Dipping a toe in the fountain of youth. Nat Aging 2, 192–194 (2022). https://doi.org/10.1038/s43587-022-00188-x