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TELOMERES

Telomere research entering the big data era

Telomeres, the caps of chromosomes, shorten with age. Using qPCR, Nilhesh Samani, Veryan Codd and colleagues measured leukocyte telomere length in close to half a million individuals from the UK Biobank, confirming several previous associations. This dataset offers many new opportunities to explore associations between leukocyte telomere length and other traits relevant to human aging and health.

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Fig. 1: LTL measurements in the UK Biobank.

References

  1. Blackburn, E. H., Epel, E. S. & Lin, J. Science 350, 1193–1198 (2015).

    Article  CAS  Google Scholar 

  2. Unryn, B. M., Cook, L. S. & Riabowol, K. T. Aging Cell 4, 97–101 (2005).

    Article  CAS  Google Scholar 

  3. Diez Roux, A. V. et al. Aging Cell 8, 251–257 (2009).

    Article  CAS  Google Scholar 

  4. Codd, V. et al, Nat. Aging, https://doi.org/10.1038/s43587-021-00166-9 (2022).

  5. Sudlow, C. et al. PLoS Med. 12, e1001779 (2015).

    Article  Google Scholar 

  6. Telomere Research Network. Study design and analysis. trn.tulane.edu, https://go.nature.com/33nX7DM (2020).

  7. Müezzinler, A., Zaineddin, A. K. & Brenner, H. Ageing Res. Rev. 12, 509–519 (2013).

    Article  Google Scholar 

  8. Gardner, M. et al. Exp. Gerontol. 51, 15–27 (2014).

    Article  CAS  Google Scholar 

  9. Demanelis, K. et al. Science 369, eaaz6876 (2020).

    Article  Google Scholar 

  10. Brown, L., Needham, B. & Ailshire, J. J. Aging Health 29, 1350–1366 (2017).

    Article  Google Scholar 

  11. De Meyer, T. et al. Human Mol Genetics 24, 3097–3102 (2007).

    Article  Google Scholar 

  12. Eisenberg, D. T. Am. J. Hum. Biol. 23, 149–167 (2011).

    Article  Google Scholar 

  13. Adams, C. D. & Boutwell, B. B. Sci. Rep. 10, 12223 (2020).

    Article  CAS  Google Scholar 

  14. Batty, G. D., Gale, C. R., Kivimäki, M., Deary, I. J. & Bell, S. Br. Med. J. 368, m131 (2020).

    Article  Google Scholar 

  15. Codd, V. et al. Nat. Genet. 53, 1425–1433 (2021).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the Strategic Research Program in Epidemiology at Karolinska Institutet, the King Gustaf V and Queen Victoria’s Foundation of Freemasons, the Start-up Grant of Sun Yat-Sen University, the National Natural Science Foundation of China (no. 72061137006) and NIH U24 AG066528-03 (principal investigator: S. Drury).

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Correspondence to Sara Hägg or Yiqiang Zhan.

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Hägg, S., Zhan, Y. Telomere research entering the big data era. Nat Aging 2, 102–104 (2022). https://doi.org/10.1038/s43587-022-00175-2

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