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EYE AGING

NAD+ boosting brings tears to aging eyes

As the elderly population continues to grow exponentially, dry eye disease is becoming increasingly common. In this issue, Sasaki and colleagues identified a NAD+-regulated steroidogenic pathway in the eye that supports the normal function of meibomian glands, and show that increasing the availability of NAD+ can alleviate the dry eye phenotype of aged mice.

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Fig. 1: Declining NAD+ availability with age contributes to meibomian gland atrophy and an evaporative dry eye phenotype.

References

  1. Lin, J. B. et al. Cell Rep. 17, 69–85 (2016).

    Article  CAS  Google Scholar 

  2. Yoshida, M. et al. Cell Metab. 30, 329–342 (2019).

    Article  CAS  Google Scholar 

  3. Yoshino, J., Baur, J. A. & Imai, S. I. Cell Metab. 27, 513–528 (2018).

    Article  CAS  Google Scholar 

  4. Lin, J. B. & Apte, R. S. Prog. Retin. Eye Res. 67, 118–129 (2018).

    Article  CAS  Google Scholar 

  5. Zhang, X. et al. Pharmaceutics 13, 893 (2021).

    Article  CAS  Google Scholar 

  6. Cimaglia, G., Votruba, M., Morgan, J. E., André, H. & Williams, P. A. Nutrients 12, 2871 (2020).

    Article  CAS  Google Scholar 

  7. Lin, J. B., Tsubota, K. & Apte, R. S. NPJ Aging Mech. Dis. 2, 16003 (2016).

    Article  Google Scholar 

  8. Sasaki, L. et al. Nat. Aging https://doi.org/10.1038/s43587-021-00167-8 (2022).

  9. Golden, M. I. & Meyer, J. J. in StatPearls, https://go.nature.com/3roRI7M (2021).

  10. Sabeti, S., Kheirkhah, A., Yin, J. & Dana, R. Surv. Ophthalmol. 65, 205–217 (2020).

    Article  Google Scholar 

  11. Rubinow, K. B. Mol. Metab. 15, 92–103 (2018).

    Article  CAS  Google Scholar 

  12. Mills, K. F. et al. Cell Metab. 24, 795–806 (2016).

    Article  CAS  Google Scholar 

  13. Ramsey, K. M. et al. Science 324, 651–654 (2009).

    Article  CAS  Google Scholar 

  14. Hägg, S. & Jylhävä, J. eLife 10, e63425 (2021).

    Article  Google Scholar 

  15. Anderson, S. T. & FitzGerald, G. A. Science 369, 1164–1165 (2020).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by NIH grant R01 EY019287-08 (R.S.A.), P30 EY02687 (Vision Core Grant), Glenn Foundation for Medical Research Award (R.S.A.), Jeffery T Fort Innovation Fund (R.S.A.), the Starr Foundation (R.S.A.) and an unrestricted grant from Research to Prevent Blindness to the John F Hardesty, MD Department of Ophthalmology and Visual Sciences at Washington University School of Medicine in Saint Louis.

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Correspondence to Rajendra S. Apte.

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R.S.A. is an inventor on a patent related to NAD+ biology, a cofounder and a member of the clinical and scientific advisory boards of Metro Biotech International. M.Y. is an inventor on a patent related to NAD+/NAMPT biology and receives patent‐licensing fees from Institute for Research on Productive Aging, Japan.

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Yoshida, M., Apte, R.S. NAD+ boosting brings tears to aging eyes. Nat Aging 2, 97–99 (2022). https://doi.org/10.1038/s43587-022-00172-5

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