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NAD+ boosting brings tears to aging eyes

As the elderly population continues to grow exponentially, dry eye disease is becoming increasingly common. In this issue, Sasaki and colleagues identified a NAD+-regulated steroidogenic pathway in the eye that supports the normal function of meibomian glands, and show that increasing the availability of NAD+ can alleviate the dry eye phenotype of aged mice.

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Fig. 1: Declining NAD+ availability with age contributes to meibomian gland atrophy and an evaporative dry eye phenotype.


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This work was supported by NIH grant R01 EY019287-08 (R.S.A.), P30 EY02687 (Vision Core Grant), Glenn Foundation for Medical Research Award (R.S.A.), Jeffery T Fort Innovation Fund (R.S.A.), the Starr Foundation (R.S.A.) and an unrestricted grant from Research to Prevent Blindness to the John F Hardesty, MD Department of Ophthalmology and Visual Sciences at Washington University School of Medicine in Saint Louis.

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Correspondence to Rajendra S. Apte.

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R.S.A. is an inventor on a patent related to NAD+ biology, a cofounder and a member of the clinical and scientific advisory boards of Metro Biotech International. M.Y. is an inventor on a patent related to NAD+/NAMPT biology and receives patent‐licensing fees from Institute for Research on Productive Aging, Japan.

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Yoshida, M., Apte, R.S. NAD+ boosting brings tears to aging eyes. Nat Aging 2, 97–99 (2022).

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