Aging-related changes in DNA methylation have been used to estimate the biological age of organisms and tissues. Measuring DNA methylation in single cells is notoriously difficult and current methods only yield sparse methylation profiles, but a new computational method now offers the capability of profiling biological age at single-cell resolution.
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Acknowledgements
I thank M. Behrends, S. Hoffmann, H. Morrison and S. Mohammad Mahdi Rasa for critical discussion. K.L.R. is supported by the Leibniz association and by the German Research Foundation (DFG, collaborative research center PolyTarget).
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Rudolph, K.L. DNA-methylation aging at single-cell level. Nat Aging 1, 1086–1087 (2021). https://doi.org/10.1038/s43587-021-00154-z
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DOI: https://doi.org/10.1038/s43587-021-00154-z
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