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MUSCLE AGING

Young extracellular vesicles rejuvenate aged muscle

Nature Aging volume 1, pages 1078–1080 (2021)Cite this article

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Exposure to young blood slows down aging of several organs and prevents physical, cognitive and immune decline. However, how circulating factors mediate these effects is poorly understood. In this issue of Nature Aging, Sahu et al.1 describe a key role for circulating extracellular vesicles in regulating skeletal muscle regeneration during aging, through the shuttling of Klotho transcripts.

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Fig. 1: Young EVs rejuvenate skeletal muscle regeneration during aging through the shuttling of Klotho transcripts.

References

  1. Sahu, A. et al. Nat. Aging https://doi.org/10.1038/s43587-021-00143-2 (2021).

  2. Conboy, I. M. et al. Nature 433, 760–764 (2005).

    Article  CAS  Google Scholar 

  3. Katsimpardi, L. et al. Science 344, 630–634 (2014).

    Article  CAS  Google Scholar 

  4. Kalluri, R. & LeBleu, V. S. Science 367, eaau6977 (2020).

    Article  CAS  Google Scholar 

  5. Blau, H. M., Cosgrove, B. D. & Ho, A. T. Nat. Med. 21, 854–862 (2015).

    Article  CAS  Google Scholar 

  6. Kuro-o, M. et al. Nature 390, 45–51 (1997).

    Article  CAS  Google Scholar 

  7. Sahu, A. et al. Nat. Commun. 9, 4859 (2018).

    Article  CAS  Google Scholar 

  8. Fry, C. S., Kirby, T. J., Kosmac, K., McCarthy, J. J. & Peterson, C. A. Cell Stem Cell 20, 56–69 (2017).

    Article  CAS  Google Scholar 

  9. Verma, M. et al. Cell Stem Cell 23, 530–543 (2018).

    Article  CAS  Google Scholar 

  10. Yoshida, M. et al. Cell Metab. 30, 329–342 (2019).

    Article  CAS  Google Scholar 

  11. Zhang, Y. et al. Nature 548, 52–57 (2017).

    Article  CAS  Google Scholar 

  12. Lei, Q. et al. Sci. Transl. Med. 13, eaaz8697 (2021).

    Article  CAS  Google Scholar 

  13. Fafián-Labora, J. A., Rodríguez-Navarro, J. A. & O’Loghlen, A. Cell Metab. 32, 71–86 (2020).

    Article  Google Scholar 

  14. Gobin, J. et al. Stem Cell Res. Ther. 12, 127 (2021).

    Article  CAS  Google Scholar 

  15. Staufer, O. et al. Sci. Adv. 7, eabg6666 (2021).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland

    Sara Ancel & Jerome N. Feige

  2. School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

    Sara Ancel & Jerome N. Feige

Authors
  1. Sara Ancel
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  2. Jerome N. Feige
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Correspondence to Jerome N. Feige.

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All authors are employees of Société des Produits Nestlé S.A., Switzerland.

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Ancel, S., Feige, J.N. Young extracellular vesicles rejuvenate aged muscle. Nat Aging 1, 1078–1080 (2021). https://doi.org/10.1038/s43587-021-00153-0

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