What makes some human brains more resilient to aging than others? In an Article in Nature Aging, Chan et al. provide evidence that brain connectomes in older adults are altered by a college education — an environmental factor that might be an advantageous modulator of brain reserve during aging.
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Chan, M. Y. et al. Nat. Aging https://doi.org/10.1038/s43587-021-00125-4 (2021).
Xu, W. et al. Mol. Neurobiol. 53, 3113–3123 (2016).
Stern, Y. Neuropsychologia 47, 2015–2028 (2009).
Bullmore, E. & Sporns, O. Nat. Rev. Neurosci. 10, 186–198 (2009).
Yu, M., Sporns, O. & Saykin, A. J. Nat. Rev. Neurol 17, 545–563 (2021).
Sepulcre, J. et al. Nat. Med. 24, 1910–1918 (2018).
Guzmán-Vélez, E. et al. Preprint in https://doi.org/10.1101/2021.07.03.450933 (2021).
Costumero, V. et al. Distance disintegration delineates the brain connectivity failure of Alzheimer’s disease. Neurobiol. Aging 88, 51–60 (2021).
The author declares no competing interests.
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Sepulcre, J. College education as a modulator of the aging brain. Nat Aging 1, 980–981 (2021). https://doi.org/10.1038/s43587-021-00131-6